Block-based compression tends to be inefficient when blocks contain arbitrary shaped discontinuities. Recently, graph-based approaches have been proposed to address this issue, but the cost of transmitting graph topology often overcome the gain of such techniques. In this work we propose a new Superpixel-driven Graph Transform (SDGT) that uses clusters of superpixels, which have the ability to adhere nicely to edges in the image, as coding blocks and computes inside these homogeneously colored regions a graph transform which is shape-adaptive. Doing so, only the borders of the regions and the transform coefficients need to be transmitted, in place of all the structure of the graph. The proposed method is finally compared to DCT and the experimental results show how it is able to outperform DCT both visually and in term of PSNR. © 2015 IEEE.