In this paper a novel technique to segment tumor voxels in dynamic positron emission tomography (PET) scans is proposed. An innovative anomaly detection tool tailored for 3-points dynamic PET scans is designed. The algorithm allows the identification of tumoral cells in dynamic FDG-PET scans thanks to their peculiar anaerobic metabolism experienced over time. The proposed tool is preliminarily tested on a small dataset showing promising performance as compared to the state of the art in terms of both accuracy and classification errors. © 2014 IEEE.